Depakote ER Side Effects

Depakote ER Side Effects

Valproic acid (VPA), an acidic chemical compound, has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. The acid, salt, or a mixture of the two (valproate semisodium) are marketed under the various brand names Depakote, Depakote ER, Depakene, Depakene Crono (extended release in Spain), Depacon, Depakine, Valparin and Stavzor. Common side effects are dyspepsia and/or weight gain. Less common are fatigue, peripheral edema, acne, dizziness, drowsiness, hair loss, headaches, nausea, sedation, and tremors. Valproic acid also causes hyperammonemia, an increase of ammonia levels in the blood, which can lead to vomiting and sluggishness, and ultimately to mental changes and brain damage. Valproate levels within the normal range are capable of causing hyperammonemia and ensuing encephalopathy. Taking lactulose may alleviate the hyperammonemia. There have been reports of the development of brain encephalopathy without hyperammonemia or elevated valproate levels. In rare circumstances, valproic acid can cause blood dyscrasia, impaired liver function, jaundice, thrombocytopenia, and prolonged coagulation (clotting) times due to a lack of blood cells.

Depakote ER Side Effects

Depakote ER Side Effects

Depakote ER Side Effects

Depakote ER Side Effects

Depakote ER Side Effects

Depakote ER Side Effects

Depakote ER Side Effects

Depakote ER Side Effects

Depakote ER Side Effects